| Cat. No. |
Product Name |
Information |
| PC-35989 |
SK609
D3R agonist
|
SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation. |
| PC-35905 |
VK4-116
D3R antagonist
|
VK4-116 (VK04-116) is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R. |
| PC-35799 |
PF-06256142
D1 dopamine agonist
|
PF-06256142 (PF06256142) is a potent and selective orthosteric agonist of the D1 receptor with EC50 (cAMP) of 33 nM, shows exquisitely selectivity over D2. |
| PC-35537 |
PCC0104005
Dopamine/5-HT modulator
|
PCC0104005 (Brilaroxazine hydrochloride) is a modulator of serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-HT2B, 5-HT6, and 5-HT7 receptors. |
| PC-35534 |
MLS1082
D1 dopamine PAM
|
MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling (EC50=123 nM). |
| PC-35533 |
MLS6585
D1 dopamine PAM
|
MLS6585 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies. |
| PC-35490 |
D-520
D2/D3 agonist
|
D-520 is a potent, multifunctional D2/D3 agonist with Ki of 41.8 /0.35 nM, modulates aggregation of alpha-synuclein (αSN) and reduces toxicity of preformed aggregates of αSN. |
| PC-35468 |
Tavapadon
Dopamine D1/D5 agonist
|
Tavapadon (CVL-751, PF-06649751) is a potent, selective orally available dopamine D1/D5 receptor partial agonist with Ki of 9 nM/13 nM, respectively. |
| PC-63551 |
Zicronapine
|
Zicronapine (Lu 31-130) is an antipsychotic agent that shows potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors, exhibits monoaminergic activity and has a multi-receptorial profile. |
| PC-63550 |
BL-1020
|
BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist. |
| PC-63349 |
BRD5814
D2R inhibitor
|
BRD5814 is a potent, selective, highly brain penetrant β-arrestin biased dopamine D2 receptor (D2R) antagonist with Ki of 0.27 uM. |
| PC-43160 |
Bromocriptine mesylate
D2R agonist
|
Bromocriptine (CB-154) is a dopamine D2 receptor agonist (Ki=3 nM) and and various serotonin receptors, also inhibits the release of glutamate by reversing the glutamate GLT1 transporter. |
