欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-ONC206
ONC206

Chemical Structure : ONC206

CAS No.: 1638178-87-6

加入收藏

ONC206 (ONC-206, ONC 206)

货号: PC-72174Not For Human Use, Lab Use Only.

ONC206 (ONC 206) is a chemical analogue of ONC201, a selective antagonist of dopamine D2-like receptor (DRD2, Ki=320 nM) with broad-spectrum anti-tumor activity.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ONC206 (ONC 206) is a chemical analogue of ONC201, a selective antagonist of dopamine D2-like receptor (DRD2, Ki=320 nM) with broad-spectrum anti-tumor activity.
ONC206 does not inhibit the D1-like (DRD 1/5), subfamily of dopamine receptors.
ONC206 has highly potent activity in preclinical models of difficult-to-treat neuroendocrine tumors and sarcomas.
ONC206 possesses a ~10-fold increased affinity for DRD2 compared to ONC201 with a Ki of ~320nM with selectivity that was superior to approved antipsychotics.
ONC206 is highly efficacious in neuroblastoma (GI50 87-589nM) including cell lines derived from metastatic sites and with MYCN amplification associated with poor prognosis.
ONC206 (100 mg/kg PO every 10 days) causes significant tumor growth inhibition in MHH-ES-1 athymic nude mice xenografts.

物理化学性质&存储条件

分子量 408.453
分子式 C23H22F2N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-benzyl-4-(2,4-difluorobenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

参考文献

1. Wagner J, et al. Cell Cycle. 2017 Oct 2;16(19):1790-1799.

2. Hu W, et al. Cancers (Basel). 2020 Aug 27;12(9):2436.

3. Staley A, et al. Am J Cancer Res. 2021 Nov 15;11(11):5374-5387.

4. Varun Vijay Prabhu, et al. Cancer Res 2017;77.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: