ML417 | D3R agonist | Probechem Biochemicals

Chemical Structure : ML417

CAS No.: 1386162-69-1

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ML417 (ML 417)

货号: PC-72158Not For Human Use, Lab Use Only.

ML417 (ML 417) is a novel potent and uniquely selective D3 dopamine receptor (D3R) full agonist with EC50 of 38 nM in β-arrestin recruitment assays.

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5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

ML417 (ML 417) is a novel potent and uniquely selective D3 dopamine receptor (D3R) full agonist with EC50 of 38 nM in β-arrestin recruitment assays. ML417 displays global selectivity at all other receptor subtypes, very limited activity (IC50 > 50 uM) at all subtypes except for the D2R, exhibits submicromolar affinity for only 3 targets, the β1-adrenergic, 5-HT2B, and σ-1 receptor in large arrays of GPCRs and several transporters or ion channels.
ML417 potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors.
ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA-induced cell death.

物理化学性质&存储条件

分子量	379.46
分子式	C22H25N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1H-indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone

参考文献

1. Moritz AE, et al. J Med Chem. 2020 May 28;63(10):5526-5567.

ML417 (ML 417)

生物&药学活性

物理化学性质&存储条件

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ML417 (ML 417)

生物&药学活性

物理化学性质&存储条件

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