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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-LY3154885
LY3154885

Chemical Structure : LY3154885

CAS No.: 2379422-72-5

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LY3154885 (LY 3154885)

货号: PC-38113Not For Human Use, Lab Use Only.

LY 3154885 is a potent dopamine D1 receptor positive allosteric modulator (PAM) with EC50 of 11.7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LY 3154885 is a potent dopamine D1 receptor positive allosteric modulator (PAM) with EC50 of 11.7 nM.
    LY 3154885 displays reduced the CYP3A4-mediated victim drug-drug interactions (DDI) risk.
    LY 3154885 possesses similar in vitro and in vivo pharmacologic properties as Mevidalen (LY 3154207), but is metabolized mainly by UGT.

    物理化学性质&存储条件

    分子量 444.356
    分子式 C23H23Cl2N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-1-methyl-5-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

    参考文献

    1. Junliang Hao, et al. J Med Chem. 2022 Mar 10;65(5):3786-3797.

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