PCC0104005 |CAS:1708960-04-6 Probechem Biochemicals

Chemical Structure : PCC0104005

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PCC0104005 (Brilaroxazine hydrochloride, RP5063 hydrochloride)

货号: PC-35537Not For Human Use, Lab Use Only.

PCC0104005 (Brilaroxazine hydrochloride) is a modulator of serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-HT2B, 5-HT6, and 5-HT7 receptors.

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生物&药学活性

PCC0104005 (Brilaroxazine hydrochloride) is a modulator of serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-HT2B, 5-HT6, and 5-HT7 receptors.
PCC0104005 binds to D2, D3 and D4 with Ki of 0.11, 0.14 and 24 nM, 5-HT2A and 5-HT2B with Ki of 5.1 and 0.34 nM.
PCC0104005 inhibits 5-HTP-induced head twitches in rats, significantly reduces the escape latency of rats and improved the MK-801-induced memory impairment, improves the recognition disorder induced by MK-801, does not produce catalepsy in mice.

物理化学性质&存储条件

分子量	486.818
分子式	C22H26Cl3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride

参考文献

1. Xu Y, et al. Sci Rep. 2018 May 2;8(1):6892.

PCC0104005 (Brilaroxazine hydrochloride, RP5063 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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PCC0104005 (Brilaroxazine hydrochloride, RP5063 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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