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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-MLS1082
MLS1082

Chemical Structure : MLS1082

CAS No.: 883958-36-9

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MLS1082 (MLS-1082, MLS 1082)

货号: PC-35534Not For Human Use, Lab Use Only.

MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling (EC50=123 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling (EC50=123 nM).
MLS1082 increase the affinity of dopamine for the D1 receptor with low micromolar potencies.

物理化学性质&存储条件

分子量 385.467
分子式 C24H23N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione

参考文献

1. Luderman KD, et al. Mol Pharmacol. 2018 Aug 1. pii: mol.118.113175.

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