(-)-IHCH7041 | DRD2 agonist | Probechem Biochemicals

Chemical Structure : (-)-IHCH7041

CAS No.: 1599089-55-0

加入收藏

(-)-IHCH7041 ((-)-IHCH 7041)

货号: PC-72176Not For Human Use, Lab Use Only.

(–)-IHCH7041 is a potent, selective partial agonist at DRD2/3 and 5-HT1AR, with EC50 of 1.38 nM in Gαi1–γ9 dissociation and 2.75 nM in β-arrestin2 recruitment assays, with negligible 5-HT2AR binding (>100-fold selectivity).

规格	价格	库存
25 mg	￥2580	In stock
100 mg	￥5580	In stock
250 mg	￥7580	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

(–)-IHCH7041 is a potent, selective partial agonist at DRD2/3 and 5-HT1AR, with EC50 of 1.38 nM in Gαi1–γ9 dissociation and 2.75 nM in β-arrestin2 recruitment assays, with negligible 5-HT2AR binding (>100-fold selectivity).
(–)-IHCH7041 exhibits negligible affinities for a large number of tested GPCRs, ion channels and transporters (Ki>500 nM), good affinities for DRD2 and DRD3 (Ki=14.42 nM), and moderate binding to 5-HT1A (Ki=60.62 nM).
(–)-IHCH7041 behaves as a partial agonist in both G-protein signaling and β-arrestin recruitment activities at DRD2, DRD3 and 5-HT1AR.
(–)-IHCH7041 displayed potent antipsychotic activity and has antidepressant properties and reverses cognitive impairmentin mice.

物理化学性质&存储条件

分子量	184.283
分子式	C10H20N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1-dimethyl-3-((1r,4r)-4-methylcyclohexyl)urea

参考文献

1. Zhangcheng Chen, et al. Nat Neurosci. 2022 Jan;25(1):39-49.

(-)-IHCH7041 ((-)-IHCH 7041)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

(-)-IHCH7041 ((-)-IHCH 7041)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.