SK609 (SK-609, ES609) | D3R agonist | Probechem Biochemicals

Chemical Structure : SK609

CAS No.: 1092797-77-7

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SK609 (SK-609, SK 609, ES609)

货号: PC-35989Not For Human Use, Lab Use Only.

SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation.

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10 mg	￥2980	In stock
25 mg	￥4980	In stock
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生物&药学活性

SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation.
SK609 reverses akinesia and reduces L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson's desease.

物理化学性质&存储条件

分子量	220.137
分子式	C10H15Cl2N
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-Chlorophenyl)butan-2-amine hydrochloride

参考文献

1. Marshall CA, et al. Neuropharmacology. 2019 Jan 8. pii: S0028-3908(19)30002-4.

2. Xu W, et al. ACS Chem Neurosci. 2017 Mar 15;8(3):486-500.

3. Kuzhikandathil EV, et al. Pharm Res. 2012 Aug;29(8):2264-75.

SK609 (SK-609, SK 609, ES609)

生物&药学活性

物理化学性质&存储条件

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SK609 (SK-609, SK 609, ES609)

生物&药学活性

物理化学性质&存储条件

参考文献

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