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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-Compound 621433144
Compound 621433144

Chemical Structure : Compound 621433144

CAS No.: 2223169-38-6

Compound 621433144 (ZINC000621433144;Z3269026405)

货号: PC-36061Not For Human Use, Lab Use Only.

Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity; Compound 621433144 was also functionally selective, with a 17-fold bias towards Gi signalling versus β-arrestin recruitment, compared to the characteristic agonist quinpirole.

物理化学性质&存储条件

分子量 301.434
分子式 C18H27N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-((3R,4S)-1-isopropyl-4-methylpyrrolidin-3-yl)-1-methylisoindoline-2-carboxamide

参考文献

1. Lyu J, et al. Nature. 2019 Feb 6. doi: 10.1038/s41586-019-0917-9.

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