| Cat. No. |
Product Name |
Information |
| PC-35683 |
SynuClean-D
α-synuclein inhibitor
|
SynuClean-D (SC-D) is a novel, small molecule inhibitor of α-synuclein (α-Syn) aggregation, incubation of 70 uM α-Syn with 100 uM SC-D impacted α-Syn aggregation in vitro, as monitored by Th-T fluorescence. |
| PC-35456 |
Leucomethylene blue mesylate
Tau aggregation inhibitor
|
Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity. |
| PC-35455 |
TRX-0237
Tau aggregation inhibitor
|
TRX-0237 (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity. |
| PC-35140 |
CID 9998128
Aβ42 inhibitor
|
CID 9998128 is a potential multi-target drug for the Alzheimer's disease (AD), inhibits the Aβ42 amyloid fibrillization and is capable to clear Aβ42 fibrils. |
| PC-35124 |
PBT434
α-synuclein inhibitor
|
PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease. |
| PC-63274 |
ELN484228
α-synuclein inhibitor
|
ELN484228 is a small molecule binder of α-synuclein that shows protective effect in cellular models of αSyn-mediated vesicular dysfunction. |
| PC-43143 |
PE859
Tau aggregation inhibitor
|
PE859 is a novel, orally active tau aggregation inhibitor that inhibits the heparin-induced aggregation of both 3RMBD and full length tau with IC50 of 0.81 uM and 2.23 uM, respectively. |
| PC-63233 |
SEN1269
Aβ aggregation inhibitor
|
SEN1269 is a potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM. |
| PC-63227 |
RU-505
Aβ42-fibrinogen inhibitor
|
RU-505 (RU505) is an effective inhibitor of the Aβ42-fibrinogen interaction with IC50 of 2.72 uM in FP assays. |
| PC-63202 |
TDI-2760
Aβ aggregation inhibitor
|
TDI-2760 is a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction (IC50=1.67 uM) but also retains potency toward the Aβ42 aggregation inhibition process. |
| PC-63196 |
BNC-1
Elk-1 activator
|
BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2. |
| PC-63133 |
GSK3039294
SAP inhibitor
|
GSK3039294 is an orally available small molecule inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils for the depletion of serum amyloid-P (SAP) component from the circulation, an orally bioavailable pro‐drug of miridesap. |
