YX-A-1 |CAS:1381156-50-8 Probechem Biochemicals

Chemical Structure : YX-A-1

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YX-A-1 (Amyloid modulator)

货号: PC-38108Not For Human Use, Lab Use Only.

YX-A-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically enhances amyloid formation.

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生物&药学活性

YX-A-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically enhances amyloid formation.
YX-A-1 accelerates wt hIAPP assembly, even when added in substoichiometric concentration ratios (e.g. at a peptide:YX-A-1 molar ratio of 1:0.5 the t50 is reduced ~1.5-fold).
YX-A-1 is a useful chemical tools to study hIAPP aggregation.

物理化学性质&存储条件

分子量	446.526
分子式	C26H27FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(cyclohexanecarboxamido)ethyl)-N-(2-fluorophenyl)-2-phenylpyrimidine-5-carboxamide

参考文献

1. Yong Xu, et al. Nat Commun. 2022 Feb 24;13(1):1040.

YX-A-1 (Amyloid modulator)

生物&药学活性

物理化学性质&存储条件

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YX-A-1 (Amyloid modulator)

生物&药学活性

物理化学性质&存储条件

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