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Leucomethylene blue mesylate

Chemical Structure : Leucomethylene blue mesylate

CAS No.: 1236208-20-0

Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine)

货号: PC-35456Not For Human Use, Lab Use Only.

Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.

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10 mg ¥680 In stock
25 mg ¥1180 In stock
50 mg ¥1980 In stock
100 mg ¥2980 In stock
250 mg Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.
Leucomethylene blue mesylate disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16 uM, delays cellular senescence and enhances key mitochondrial biochemical pathways.
Leucomethylene blue mesylate demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain.

物理化学性质&存储条件

分子量 379.493
分子式 C17H21N3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,7-bis(dimethylamino)phenothiazin-5-ium methanesulfonate

参考文献

1. Harrington CR, et al. J Biol Chem. 2015 Apr 24;290(17):10862-75.

2. Atamna H, et al. FASEB J. 2008 Mar;22(3):703-12.

3. Seripa D, et al. Expert Rev Neurother. 2016;16(3):259-77.

4. Wilcock GK, et al. J Alzheimers Dis. 2018;61(1):435-457.

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