YX-I-1 |CAS:2125571-84-6 Probechem Biochemicals

Chemical Structure : YX-I-1

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YX-I-1

货号: PC-38109Not For Human Use, Lab Use Only.

YX-I-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically inhibits amyloid formation.

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生物&药学活性

YX-I-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically inhibits amyloid formation.
YX-I-1 inhibits the aggregation of wt hIAPP, extending the t50 from 15.1 ± 0.2 h to 23.4 ± 1.0 h at a 1:7 molar ratio of peptide:inhibitor.
YX-I-1 inhibits primary nucleation, secondary nucleation and elongation of wt hIAP.
YX-A-1 is a useful chemical tools to study hIAPP aggregation.

物理化学性质&存储条件

分子量	435.528
分子式	C24H29N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((2S,4R,6R)-4-acetamido-6-isopropyltetrahydro-2H-pyran-2-yl)phenyl)-2-(1H-benzo[d][1,2,3]triazol-1-yl)acetamide

参考文献

1. Yong Xu, et al. Nat Commun. 2022 Feb 24;13(1):1040.

YX-I-1

生物&药学活性

物理化学性质&存储条件

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YX-I-1

生物&药学活性

物理化学性质&存储条件

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