SynuClean-D |CAS:685121-45-3 Probechem Biochemicals

Chemical Structure : SynuClean-D

CAS No.: 685121-45-3

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SynuClean-D (SC-D)

货号: PC-35683Not For Human Use, Lab Use Only.

SynuClean-D (SC-D) is a novel, small molecule inhibitor of α-synuclein (α-Syn) aggregation, incubation of 70 uM α-Syn with 100 uM SC-D impacted α-Syn aggregation in vitro, as monitored by Th-T fluorescence.

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5 mg	￥3580	In stock
10 mg	￥5580	In stock
25 mg	￥8980	In stock
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生物&药学活性

SynuClean-D (SC-D) is a novel, small molecule inhibitor of α-synuclein (α-Syn) aggregation, incubation of 70 uM α-Syn with 100 uM SC-D impacted α-Syn aggregation in vitro, as monitored by Th-T fluorescence。
SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio, prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells。
SynuClean-D binds to cavities in mature α-synuclein fibrils and displays a strong fibril disaggregation activity。
SynuClean-D significantly reduces the toxicity exerted by α-synuclein, also rescues dopaminergic neurons from α-synuclein-induced degeneration in Parkinson's disease models.

物理化学性质&存储条件

分子量	354.201
分子式	C13H5F3N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydroxy-5-nitro-6-(3-nitrophenyl)-4-(trifluoromethyl)nicotinonitrile

参考文献

1. Pujols J, et al. Proc Natl Acad Sci U S A. 2018 Sep 24. pii: 201804198.

SynuClean-D (SC-D)

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物理化学性质&存储条件

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