SEN1269 | Aβ aggregation inhibitor | Probechem Biochemicals

Chemical Structure : SEN1269

加入收藏

SEN1269 (SEN-1269)

货号: PC-63233Not For Human Use, Lab Use Only.

SEN1269 is a potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SEN1269 is a potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM.
SEN1269 produces a concentration-related blockade of Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42).
SEN1269 alleviates deficits in hippocampal LTP induced by Aβ(1-42) and cell-derived Aβ oligomers.
SEN1269 reduces Aβ-induced neurotoxicity and shows neuroprotective in behavioural models of memory relevant to Aβ-induced neurodegeneration.

物理化学性质&存储条件

分子量	322.368
分子式	C18H18N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((5-(3-(dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol

参考文献

1. Scopes DI, et al. Br J Pharmacol. 2012 Sep;167(2):383-92.

SEN1269 (SEN-1269)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SEN1269 (SEN-1269)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.