RU-505 (RU505)

Chemical Structure : RU-505

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货号: PC-63227Not For Human Use, Lab Use Only.

RU-505 (RU505) is an effective inhibitor of the Aβ42-fibrinogen interaction with IC50 of 2.72 uM in FP assays.

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生物&药学活性

RU-505 (RU505) is an effective inhibitor of the Aβ42-fibrinogen interaction with IC50 of 2.72 uM in FP assays.
RU-505 restores Aβ-induced altered fibrin clot formation and degradation in vitro and inhibits vessel occlusion in AD transgenic mice,.
RU-505 significantly reduces vascular amyloid deposition and microgliosis in the cortex and improves cognitive impairment in mouse models of AD.

物理化学性质&存储条件

分子量	473.596
分子式	C28H32FN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-(dimethylamino)ethyl]-2-(1,1-dimethylethyl)-7-(4-fluorophenyl)-N-(phenylmethyl)-pyrazolo[1,5-a]pyrimidine-5-carboxamide

参考文献

1. Ahn HJ, et al. J Exp Med. 2014 Jun 2;211(6):1049-62.

RU-505 (RU505)

生物&药学活性

物理化学性质&存储条件

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RU-505 (RU505)

生物&药学活性

物理化学性质&存储条件

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