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NPT200-11

Chemical Structure : NPT200-11

CAS No.: 1802518-63-3

NPT200-11 ((Rac)-Minzasolmin, (Rac)-UCB0599)

货号: PC-35764Not For Human Use, Lab Use Only.

NPT200-11 is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor.

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5 mg ¥3880 In stock
10 mg ¥5580 In stock
25 mg ¥8980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NPT200-11 ((Rac)-Minzasolmin, (Rac)-UCB0599) is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor.
NPT200-11 reduced retinal alpha-synuclein pathology in cortex, reduced associated neuroinflammation (astrogliosis), normalized striatal levels of the dopamine transporter (DAT) and improved motor function in animal model of Parkinson's disease.

物理化学性质&存储条件

分子量 425.60
分子式 C23H31N5OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(1-(1H-indol-3-yl)hexan-2-yl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide

参考文献

1. Price DL, et al. Sci Rep. 2018 Nov 1;8(1):16165.

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