PE859 | Tau aggregation inhibitor | Probechem Biochemicals

Chemical Structure : PE859

CAS No.: 1402727-29-0

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PE859 (PE-859, PE 859)

货号: PC-43143Not For Human Use, Lab Use Only.

PE859 is a novel, orally active tau aggregation inhibitor that inhibits the heparin-induced aggregation of both 3RMBD and full length tau with IC50 of 0.81 uM and 2.23 uM, respectively.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

PE859 is a novel, orally active tau aggregation inhibitor that inhibits the heparin-induced aggregation of both 3RMBD and full length tau with IC50 of 0.81 uM and 2.23 uM, respectively.
PE859 also inhibits amyloid β (Aβ) aggregation with IC50 of 1.2 uM.
PE859 significantly reduces sarkosyl-insoluble aggregated tau along with the prevention of onset and progression of the motor dysfunction in JNPL3 P301L-mutated human tau transgenic mice.

物理化学性质&存储条件

分子量	448.5157
分子式	C28H24N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	1H-Indole, 6-[(1E)-2-[5-[(1E)-2-[2-methoxy-4-(2-pyridinylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-

参考文献

1. Okuda M, et al. PLoS One. 2015 Feb 6;10(2):e0117511.

2. Okuda M, et al. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5024-5028.

3. Okuda M, et al. J Alzheimers Dis. 2017;59(1):313-328.

PE859 (PE-859, PE 859)

生物&药学活性

物理化学性质&存储条件

参考文献

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PE859 (PE-859, PE 859)

生物&药学活性

物理化学性质&存储条件

参考文献

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