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ELN484228

Chemical Structure : ELN484228

CAS No.: 312-63-0

ELN484228 (ELN 484228)

货号: PC-63274Not For Human Use, Lab Use Only.

ELN484228 is a small molecule binder of α-synuclein that shows protective effect in cellular models of αSyn-mediated vesicular dysfunction.

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50 mg ¥1580 In stock
100 mg ¥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ELN484228 is a small molecule binder of α-synuclein that shows protective effect in cellular models of αSyn-mediated vesicular dysfunction.
ELN484228 rescues α-synuclein-induced disruption of vesicle trafficking and dopaminergic neuronal loss and neurite retraction most likely by reducing the amount of α-synuclein targeted to sites of vesicle mobilization such as the synapse in neurons or the site of bead engulfment in microglial cells.
ELN484228 shows potential therapeutic strategy for Parkinson's disease.

物理化学性质&存储条件

分子量 251.28
分子式 C12H10FNO2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-Fluorophenyl)-benzenesulfonamide

参考文献

1. Tóth G, et al. PLoS One. 2014 Feb 14;9(2):e87133.

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