| Cat. No. |
Product Name |
Information |
| PC-22455 |
FS2921
GluN1/GluN2A NMDAR PAM
|
FS2921 is a potential, functionally selective GluN1/GluN2A positive allosteric modulator (PAM), selective versus GluN1/GluN2B and GluN1/GluN2D, increases NMDAR-mediated currents with EC50 of 8.8 uM. |
| PC-22454 |
GNE-6901
GluN2A PAM
|
GNE-6901 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM) wIth EC50 of 382 nM, binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22453 |
GNE-8324
GluN2A PAM
|
GNE-8324 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM), binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22452 |
Apimostinel
NMDAR agonist
|
Apimostinel (NRX-1074; AGN-241660) is a potential, orally active antidepressant and NMDAR partial agonist. |
| PC-22451 |
MPX-007
GluN2A antagonist
|
MPX-007 is a selective GluN2A antagonist, inhibits GluN2A-containing NMDA receptors expressed in HEK cells with IC50 of 27 nM. |
| PC-22449 |
TCN213
GluN2A antagonist
|
TCN213 is a selective, glycine-dependently GluN2A-containing NMDARs antagonist with IC50 of 0.55 uM for GluN1/GluN2A NMDAR, negligible effect on GluN1/GluN2B NMDA receptor. |
| PC-22425 |
CX1739
AMPAR modulator
|
CX1739 is a small molecule AMPAR allosteric modulator. |
| PC-22280 |
Ro 25-6981
NMDA NR2B inhibitor
|
Ro 25-6981 is a potent and selective antagonist of NMDA receptors containing NR2B subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. |
| PC-22279 |
Ro 25-6981 maleate
NMDA NR2B inhibitor
|
Ro 25-6981 maleate is a potent and selective antagonist of NMDA receptors containing NR2B subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. |
| PC-22159 |
HU-210
NMDAR antagonist
|
HU-211 is a functional N-methyl-D-aspartate receptor blocker with IC50 of 6-10 uM for glutamate- or glycine-induced binding. |
| PC-21853 |
Zelquistinel
NMDAR modulator
|
Zelquistinel (AGN-241751) is an orally active NMDAR allosteric modulator, exhibits antidepressant-like activity via positive modulation of GluN2B containing NMDARs in mPFC excitatory neurons. |
| PC-21624 |
ZCAN155
GluA2 modualtor
|
ZCAN155 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=35 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2), restores neurological function and myelination. |
