| Cat. No. |
Product Name |
Information |
| PC-23317 |
MDL-29951
GPR17 agonist, NMDAR antagonist
|
MDL-29951 (MDL-29, 951) is a potent glycine antagonist of NMDA receptor with Ki of 0.14 uM for [3H]glycine binding in vitro, also is a potent GPR17 agonist with pEC50 of 6.48. |
| PC-23271 |
CX1942
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
| PC-23270 |
CX1763
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
| PC-23269 |
EU1622-240
NMDAR PAM
|
EU1622-240 is a positive allosteric modulator of NMDA receptors (NMDARs), enhances current response to saturating agonist (doubling response amplitude at 0.2-0.5 µM). |
| PC-23086 |
Nevadistinel
NMDAR PAM
|
Nevadistinel (NYX-458, NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor. |
| PC-23082 |
Risevistinel
NMDAR PAM
|
Risevistinel (NYX-783, NYX783) is a potent, specific NMDAR positive allosteric-modulator. |
| PC-22610 |
NS3763
GLUK5 antagonist
|
NS3763 is a noncompetitive antagonist of GLUK5 receptor, inhibits domoate-induced increase in intracellular calcium mediated through the GLU(K5) of kainate receptors with IC50 of 1.6 uM, with no effect on GLU(K6) subtype. |
| PC-22609 |
3-Hydroxykynurenine
iGluR modulator
|
3-Hydroxykynurenine (3-HK) is a metabolite produced through host tryptophan metabolism, restricts bacterial expansion in macrophages via a systemic mechanism, modulates the activity of iGluR receptors of the AMPAR and KAR subclasses. |
| PC-22608 |
Rapastinel trifluoroacetate
NMDAR agonist
|
Rapastinel (GLYX-13, Thr-Pro-Pro-Thr-NH2) trifluoroacetateis a tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist. |
| PC-22455 |
FS2921
GluN1/GluN2A NMDAR PAM
|
FS2921 is a potential, functionally selective GluN1/GluN2A positive allosteric modulator (PAM), selective versus GluN1/GluN2B and GluN1/GluN2D, increases NMDAR-mediated currents with EC50 of 8.8 uM. |
| PC-22454 |
GNE-6901
GluN2A PAM
|
GNE-6901 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM) wIth EC50 of 382 nM, binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22453 |
GNE-8324
GluN2A PAM
|
GNE-8324 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM), binds to the GluN1/GluN2A LBD dimer interface. |
