| Cat. No. |
Product Name |
Information |
| PC-42745 |
LY450108
AMPAR PAM
|
LY450108 is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors. |
| PC-42744 |
LY451395
AMPAR PAM
|
Mibampator (LY451395) is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors. |
| PC-42691 |
Rislenemdaz
GluN2B antagonist
|
Rislenemdaz (MK-0657, CERC-301) is a potent, orally bioavailable brain-penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively, with no off-target activity. |
| PC-45532 |
L-701324
NMDAR antagonist
|
L-701324 (L-701,324) is a potent, orally active antagonist at the glycine modulatory site on NMDA receptor with IC50 of 2 nM. |
| PC-42742 |
Aniracetam
AMPAR PAM
|
Aniracetam (Ro 13-5057) is a positive allosteric modulator of AMPAR, potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. |
| PC-42743 |
Ampalex
AMPAR PAM
|
Ampalex (CX516) is a positive allosteric modulator of AMPA, increases fast, excitatory (glutamatergic) synaptic responses in hippocampal slices by about 50% with an EC50 of 170 uM. |
| PC-42746 |
Farampator
AMPAR PAM
|
Farampator (CX-691, Org24448) is a positive allosteric modulator of AMPAR as ampakine agent. |
| PC-45344 |
Sunifiram
AMPAR agonist
|
Sunifiram (DM-253) is a piperazine derived ampakine-like agent, is an agonist of AMPA receptor with oral activity, exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam. |
| PC-26935 |
Memantine
NMDA receptor antagonist
|
Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist with Ki of 0.19 uM for competing with [3H]MK-801 binding in membrane homogenates of postmortem human frontal cortex. |
| PC-26837 |
Fluoroethylnormemantine
NMDA receptor antagonist
|
Fluoroethylnormemantine (FENM) is a structural analogue of Memantine and NMDA receptor antagonist with Ki of 3.5 uM, exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects. |
| PC-26348 |
Otefprodil
GluN2B antagonist
|
Otefprodil is a potent, selective antagonist of NR2B (GluN2B)-containing NMDA receptors, inhibits glutamic acid and glycine induced activation. |
| PC-26281 |
CGP-78608 hydrochloride
GluN1 antagonist
|
CGP 78608 hydrochloride is a highly potent and selective antagonist of GluN1/GluN3 NMDAR, antagonizes GluN1/GluN2 receptors, acts as an ultra-potent and powerful potentiator of GluN1/GluN3A receptors. |
