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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-LY450108
LY450108

Chemical Structure : LY450108

CAS No.: 376594-67-1

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LY450108 (LY 450108, LY-450108)

货号: PC-42745Not For Human Use, Lab Use Only.

LY450108 is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg ￥5480 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY450108 is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.

物理化学性质&存储条件

分子量 396.4514
分子式 C19H22F2N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 3,5-difluoro-N-[4-[(1R)-1-methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]-

参考文献

1. O'Neill MJ, et al. Curr Drug Targets. 2007 May;8(5):603-20.

2. Jhee SS, et al. J Clin Pharmacol. 2006 Apr;46(4):424-32.

3. O'Neill MJ, et al. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94.

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