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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-SYM2206
SYM2206

Chemical Structure : SYM2206

CAS No.: 173952-44-8

SYM2206 (SYM-2206)

货号: PC-45528Not For Human Use, Lab Use Only.

SYM2206 is an allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SYM2206 is an allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM.
SYM2206 acts allosterically at the same regulatory site as GYKI 52466 and 53655 and other benzodiazepines but does not bind to the central diazepine binding site.
SYM2206 shows selectivity for AMPA relative to kainate receptor sub-types.

物理化学性质&存储条件

分子量 366.4137
分子式 C20H22N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3-Dioxolo[4,5-g]phthalazine-6(5H)-carboxamide, 8-(4-aminophenyl)-5-methyl-N-propyl-

参考文献

1. Pei XF, et al. Bioorg Med Chem Lett. 1999 Feb 22;9(4):539-42.

2. Li P, et al. Nature. 1999 Jan 14;397(6715):161-4.

3. Behr J, et al. Eur J Neurosci. 2002 Sep;16(5):861-7.

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