| Cat. No. |
Product Name |
Information |
| PC-28572 |
SMU-H1
TLR2 agonist
|
SMU-H1 is a potent, selective TLR2 agonist with EC50 of 5.14 nM, binds TLR2 to recruit MyD88, activates the MAPK/NF-κB pathways, and induces proinflammatory cytokines. |
| PC-28204 |
SMU-C409
TLR1/2 agonist
|
SMU-C409 is a potent, specific small molecule TLR1/2 agonist with EC50 of 65 nM, activates TLR1/2, recruits MyD88, induces NF-κB phosphorylation, and stimulates TNF-α/IL-1β secretion, induces robust immune cell activation and antitumor immunomodulation. |
| PC-27775 |
ER-899742
TLR7/8 antagonist
|
ER-899742 is a potent, selective dual antagonist of TLR7/8 with IC50 of 15/16 nM for hTLR7/8 respectively, with no activity against hTLR9. |
| PC-26696 |
AXC-715 hydrochloride
TLR7 agonist
|
AXC-715 (T785) hydrochloride is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26695 |
AXC-715
TLR7 agonist
|
AXC-715 (T785) is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26660 |
L48H37
TLR4 inhibitor, MD2 inhibitor
|
L48H37 is a curcumin analog that specifically targets myeloid differentiation protein 2 (MD2) and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. |
| PC-26478 |
ENDO12
STX7-Munc13-4 inhibitor, eTLR inhibitor
|
ENDO12 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG, directly binds to recombinant STX7 with SPR KD of 2.7 uM. |
| PC-26477 |
ENDO3
STX7-Munc13-4 inhibitor
|
ENDO3 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG with IC50 of 0.12 uM, directly binds to recombinant STX7 with SPR KD of 3.13 uM. |
| PC-26302 |
BXY-14
TLR2 agonist
|
BXY-14 is a highly potent TLR2 agonist, stimulates TNF-α release with EC50 of 2.2 nM and 1.8 nM in human THP-1 cells and mBMDCs respectively. |
| PC-26179 |
PVP-057
TLR3 agonist
|
PVP-057 is a specific small molecule Toll-like receptor 3 (TLR3) agonist, activates TLR3-dependent IRF and NF-kB signaling. |
| PC-25826 |
NSF-951
TLR4 agonist
|
NSF-951 is a small molecule TLR4 agonist with binding KD of 16.01 uM, induces the pro-inflammatory cytokines via MyD88/TRIF signalling. |
| PC-25546 |
TLR9 antagonist 38
TLR9 antagonist
|
TLR9 antagonist 38 is a highly potent, selective TLR9 antagonist with IC50 of 0.1 nM (hTLR9), >10,000-fold selectivity over hTLR2/4/5/7/8. |
