| Cat. No. |
Product Name |
Information |
| PC-28204 |
SMU-C409
TLR1/2 agonist
|
SMU-C409 is a potent, specific small molecule TLR1/2 agonist with EC50 of 65 nM, activates TLR1/2, recruits MyD88, induces NF-κB phosphorylation, and stimulates TNF-α/IL-1β secretion, induces robust immune cell activation and antitumor immunomodulation. |
| PC-27775 |
ER-899742
TLR7/8 antagonist
|
ER-899742 is a potent, selective dual antagonist of TLR7/8 with IC50 of 15/16 nM for hTLR7/8 respectively, with no activity against hTLR9. |
| PC-26696 |
AXC-715 hydrochloride
TLR7 agonist
|
AXC-715 (T785) hydrochloride is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26695 |
AXC-715
TLR7 agonist
|
AXC-715 (T785) is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26478 |
ENDO12
STX7-Munc13-4 inhibitor, eTLR inhibitor
|
ENDO12 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG, directly binds to recombinant STX7 with SPR KD of 2.7 uM. |
| PC-26302 |
BXY-14
TLR2 agonist
|
BXY-14 is a highly potent TLR2 agonist, stimulates TNF-α release with EC50 of 2.2 nM and 1.8 nM in human THP-1 cells and mBMDCs respectively. |
| PC-26179 |
PVP-057
TLR3 agonist
|
PVP-057 is a specific small molecule Toll-like receptor 3 (TLR3) agonist, activates TLR3-dependent IRF and NF-kB signaling. |
| PC-25826 |
NSF-951
TLR4 agonist
|
NSF-951 is a small molecule TLR4 agonist with binding KD of 16.01 uM, induces the pro-inflammatory cytokines via MyD88/TRIF signalling. |
| PC-25546 |
TLR9 antagonist 38
TLR9 antagonist
|
TLR9 antagonist 38 is a highly potent, selective TLR9 antagonist with IC50 of 0.1 nM (hTLR9), >10,000-fold selectivity over hTLR2/4/5/7/8. |
| PC-25128 |
SMU-C80
TLR1/2 agonist
|
SMU-C80 is a highly efficient and specific human TLR1/2 agonist, effectively promotes the SEAP signals in HEK-Blue hTLR2 cells with EC50 of 31.02 nM. |
| PC-25127 |
CU-T12-9
TLR1/2 agonist
|
CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM, directly targets TLR1/2 to initiate downstream signaling, induces TLR1/2 heterodimerization. |
| PC-25125 |
SMU-C68
TLR1/2 agonist
|
SMU-C68 is a potent, selective human TLR1/2 agonist with EC50 of 9 nM in HEK-Blue hTLR2 cells, selectively targets the TLR1/2 heterodimer. |
