| Cat. No. |
Product Name |
Information |
| PC-38433 |
Zenuzolac
Immunosuppressant
|
Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders. |
| PC-73443 |
Ruzotolimod
TLR7 agonist
|
Ruzotolimod (RO7020531) is a potent, selective, oral TLR7 agonist in clinical development as part of a curative regimen against chronic hepatitis B. |
| PC-73105 |
CU-72
TLR7/8 inhibitor
|
CU-72 is a potent, selective TLR7/8 dual inhibitor with IC50 of 5.10 and 2.87 uM, respectively. |
| PC-73063 |
1V209
TLR7 agonist
|
1V209 is a synthetic small molecule TLR7 specific ligand and agonist. |
| PC-72474 |
BMS-986256
TLR7/8 inhibitor
|
BMS-986256 (Afimetoran, BMS986256) is an orally active, potent and selective inhibitor antagonist of TLR7/8. |
| PC-72053 |
CU-CPD107
TLR8 agonist
|
CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA. |
| PC-72052 |
CU-115
TLR8 inhibitor
|
CU-115 is a novel potent, selective TLR8 antagonist (inhibitor) with IC50 of 1.4 uM, shows no significant inhibitory effect on TLR7 (IC50>50 uM). |
| PC-72051 |
BMS-615
TLR789 inhibitor
|
TLR789 inhibitor 7f (BMS-615) is a potent, orally bioavailable antagonist of Toll-like Receptor 7/8/9 (TLR7/8/9) with IC50 of 10/17/700 nM in NF-kB reporter assays, does not inhibit TLR3/4. |
| PC-72050 |
SM360320
TLR7 agonist
|
SM360320 (CL-087, 1V136) is a potent, orally active and selective TLR7 agonist (ligand). |
| PC-72049 |
M5049
TLR7/8 inhibitor
|
M5049 (Enpatoran, M-5049) is a novel potent, selective TLR7/8 inhibitor with IC50 of 11.1/24.1 nM in HEK NF-kB-luciferase reporter cells assay, repectively |
| PC-38135 |
CU-CPT22
TLR1/TLR2 inhibitor
|
CU-CPT22 is a specific small-molecule inhibitor of the TLR1/TLR2 complex with IC50 of 0.58 uM (NO production in RAW 264.7 cells). |
| PC-38134 |
MMG-11
TLR2 inhibitor
|
MMG-11 (MMG11) is a potent and selective TLR2 antagonist with pA2 values of 5.73 and 6.15 (TLR2/1), preferentially inhibits TLR2/1 signaling. |
