CU-CPT4a | TLR3 inhibitor | Probechem Biochemicals

Chemical Structure : CU-CPT4a

CAS No.: 1279713-77-7

加入收藏

CU-CPT4a (TLR3-dsRNA complex inhibitor, TLR3i)

货号: PC-20180Not For Human Use, Lab Use Only.

TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM.
TLR3/dsRNA Complex Inhibitor (TLR3i) inhibits TLR3 signaling without affecting other TLRs (TLR1/2, TLR2/6, TLR3, TLR4, and TLR7).
TLR3/dsRNA Complex Inhibitor disrupts the TLR3/dsRNA association by directly targeting the RNA-binding site on TLR3.
TLR3/dsRNA Complex Inhibitor also inhibits the downstream signaling transduction mediated by the formation of the TLR3/dsRNA complex. TLR3/dsRNA Complex Inhibitor abolishes the TNF-α and IL-1β production activated by 15 µg/ml Poly (I:C) in the RAW 264.7 cells with IC90 of 27 uM.

物理化学性质&存储条件

分子量	377.81
分子式	C18H13ClFNO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-chloro-6-fluorobenzo[b]thiophene-2-carbonyl)-D-phenylalanine

参考文献

1. Cheng K, et al. J Am Chem Soc. 2011 Mar 23;133(11):3764-7.

CU-CPT4a (TLR3-dsRNA complex inhibitor, TLR3i)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CU-CPT4a (TLR3-dsRNA complex inhibitor, TLR3i)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.