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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-TL8-506
TL8-506

Chemical Structure : TL8-506

CAS No.: 1268163-15-0

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TL8-506 (TL 8-506 )

货号: PC-20228Not For Human Use, Lab Use Only.

TL8-506 is a potent, selective TLR8 agonist with EC50 of 30 nM for inducing NF-κB activation in TLR8-transfeceted HEK293 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TL8-506 is a potent, selective TLR8 agonist with EC50 of 30 nM for inducing NF-κB activation in TLR8-transfeceted HEK293 cells.
    TL8-506 is also a TLR8 ligand more potent than resiquimod and 3M-002.

    物理化学性质&存储条件

    分子量 331.38
    分子式 C20H17N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 2-amino-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate

    参考文献

    1. Cindy Patinote, et al. Eur J Med Chem. 2020 May 1; 193: 112238.

    2. Patra MC, et al. Cells. 2020 Jul 9;9(7):1648.

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