AZD8848 | TLR7 agonist | Probechem Biochemicals

Chemical Structure : AZD8848

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AZD8848 (AZD-8848)

货号: PC-20229Not For Human Use, Lab Use Only.

AZD8848 (AZD 8848) is a potent, selective TLR7 agonist with EC50 of 4 nM for induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for inhibition of IL-5.

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生物&药学活性

AZD8848 (AZD 8848) is a potent, selective TLR7 agonist with EC50 of 4 nM for induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for inhibition of IL-5.
AZD8848 has no activity against human TLR8 or against any of the other human TLRs.
AZD8848 is efficacious at reducing OVA-induced inflammation in the lung in the Brown Norway rat model.

物理化学性质&存储条件

分子量	569.71
分子式	C29H43N7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-(3-(((3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl)(3-morpholinopropyl)amino)methyl)phenyl)acetate

参考文献

1. Greiff L, et al. Respir Res. 2012 Jun 22;13(1):53.

2. Delaney S, et al. BMJ Open Respir Res. 2016 Feb 23;3(1):e000113.

AZD8848 (AZD-8848)

生物&药学活性

物理化学性质&存储条件

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AZD8848 (AZD-8848)

生物&药学活性

物理化学性质&存储条件

参考文献

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