| Cat. No. |
Product Name |
Information |
| PC-26536 |
TLR8 antagonist 35
TLR8 inhibitor
|
TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells. |
| PC-26477 |
ENDO3
STX7-Munc13-4 inhibitor
|
ENDO3 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG with IC50 of 0.12 uM, directly binds to recombinant STX7 with SPR KD of 3.13 uM. |
| PC-26302 |
BXY-14
TLR2 agonist
|
BXY-14 is a highly potent TLR2 agonist, stimulates TNF-α release with EC50 of 2.2 nM and 1.8 nM in human THP-1 cells and mBMDCs respectively. |
| PC-25546 |
TLR9 antagonist 38
TLR9 antagonist
|
TLR9 antagonist 38 is a highly potent, selective TLR9 antagonist with IC50 of 0.1 nM (hTLR9), >10,000-fold selectivity over hTLR2/4/5/7/8. |
| PC-25491 |
ETI60
TLR inhibitor
|
ETI60 (endosomal TLR inhibitor 60) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 20-3 00 nM for TLR3, TLR7 and TLR9, and 2 uM for TLR8. |
| PC-25490 |
ETI41
TLR inhibitor
|
ETI41 (endosomal TLR inhibitor 41) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 100-1000 nM. |
| PC-25432 |
CL097
TLR7/8 agonist
|
CL097 is a specific small molecule TLR-7/TLR-8 agonist, inhibits TLR-4--dependent activation of IRAK-M and BCL-3 expression, induces human pDC activation. |
| PC-25430 |
SMU-L11
TLR7 agonist
|
SMU-L11 is a potent, selecitve small-molecule TLR7 agonist with EC50 of 24 nM (hTLR7). |
| PC-25313 |
TLR7/8 antagonist 1
TLR7/8 antagonist
|
TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β. |
| PC-25312 |
TLR 7/8 agonist 558
TLR7/8 agonist
|
TLR 7/8 agonist 558 (TLR7/8 agonist 6) is a potent TLR7 and TLR8 small molecule agonist with EC50 of 0.18 uM and 5.34 uM respectively, stimulates TNFα, IFNγ, and IL-1β. |
| PC-25128 |
SMU-C80
TLR1/2 agonist
|
SMU-C80 is a highly efficient and specific human TLR1/2 agonist, effectively promotes the SEAP signals in HEK-Blue hTLR2 cells with EC50 of 31.02 nM. |
| PC-25127 |
CU-T12-9
TLR1/2 agonist
|
CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM, directly targets TLR1/2 to initiate downstream signaling, induces TLR1/2 heterodimerization. |
