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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-CU-CPT9b
CU-CPT9b

Chemical Structure : CU-CPT9b

CAS No.: 2162962-69-6

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CU-CPT9b (TLR8 inhibitor 9b)

货号: PC-60332Not For Human Use, Lab Use Only.

CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity.
CU-CPT9b shows no significant inhibition for other TLRs at 1 uM in cellular assays.
CU-CPT9b consistently recognizes an allosteric pocket on the protein-protein interface, stabilizing the inactive TLR8 dimer.

物理化学性质&存储条件

分子量 251.285
分子式 C16H13NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-hydroxy-3-methylphenyl)quinolin-7-ol

参考文献

1. Zhang S, et al. Nat Chem Biol. 2017 Nov 20. doi: 10.1038/nchembio.2518.

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