| Cat. No. |
Product Name |
Information |
| PC-60331 |
CU-CPT9a
TLR8 inhibitor
|
CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity. |
| PC-60002 |
CU-CPT-8m
TLR8 inhibitor
|
CU-CPT-8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity. |
| PC-42165 |
TL2-C29
TLR2 inhibitor
|
TL2-C29 (TLR2 inhibitor C29) is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells. |
| PC-26537 |
TH1027
TLR8 inhibitor
|
TH1027 is a highly potent and specific inhibitor of TLR8, dose-dependently inhibited R848-or ssRNA06-induced TLR8 activation with IC50 of 30 nM. |
| PC-26536 |
TLR8 antagonist 35
TLR8 inhibitor
|
TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells. |
| PC-26477 |
ENDO3
STX7-Munc13-4 inhibitor
|
ENDO3 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG with IC50 of 0.12 uM, directly binds to recombinant STX7 with SPR KD of 3.13 uM. |
| PC-26302 |
BXY-14
TLR2 agonist
|
BXY-14 is a highly potent TLR2 agonist, stimulates TNF-α release with EC50 of 2.2 nM and 1.8 nM in human THP-1 cells and mBMDCs respectively. |
| PC-26179 |
PVP-057
TLR3 agonist
|
PVP-057 is a specific small molecule Toll-like receptor 3 (TLR3) agonist, activates TLR3-dependent IRF and NF-kB signaling. |
| PC-25826 |
NSF-951
TLR4 agonist
|
NSF-951 is a small molecule TLR4 agonist with binding KD of 16.01 uM, induces the pro-inflammatory cytokines via MyD88/TRIF signalling. |
| PC-25546 |
TLR9 antagonist 38
TLR9 antagonist
|
TLR9 antagonist 38 is a highly potent, selective TLR9 antagonist with IC50 of 0.1 nM (hTLR9), >10,000-fold selectivity over hTLR2/4/5/7/8. |
| PC-25491 |
ETI60
TLR inhibitor
|
ETI60 (endosomal TLR inhibitor 60) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 20-3 00 nM for TLR3, TLR7 and TLR9, and 2 uM for TLR8. |
| PC-25490 |
ETI41
TLR inhibitor
|
ETI41 (endosomal TLR inhibitor 41) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 100-1000 nM. |
