| Cat. No. |
Product Name |
Information |
| PC-61095 |
CPG-52364
TLR7/8/9 antagonist
|
CPG-52364 (CPG52364) is an orally available, small molecule TLR7/8/9 antagonist for the treatment of systemic lupus erythematosus and other autoimmune disorders.. |
| PC-60332 |
CU-CPT9b
TLR8 inhibitor
|
CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity. |
| PC-60331 |
CU-CPT9a
TLR8 inhibitor
|
CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity. |
| PC-60002 |
CU-CPT-8m
TLR8 inhibitor
|
CU-CPT-8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity. |
| PC-42165 |
TL2-C29
TLR2 inhibitor
|
TL2-C29 (TLR2 inhibitor C29) is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells. |
| PC-26844 |
Agatolimod
TLR9 agonist
|
Agatolimod ((ODN2006, PF-3512676; CpG 7909)) is an immunomodulating synthetic oligonucleotide designed to specifically agonise the Toll-like receptor 9 (TLR9) with EC50 of 180 nM against human TLR9. |
| PC-26697 |
AXC-715 trihydrochloride
TLR7 agonist
|
AXC-715 (T785) trihydrochloride is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26696 |
AXC-715 hydrochloride
TLR7 agonist
|
AXC-715 (T785) hydrochloride is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26695 |
AXC-715
TLR7 agonist
|
AXC-715 (T785) is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26660 |
L48H37
TLR4 inhibitor, MD2 inhibitor
|
L48H37 is a curcumin analog that specifically targets myeloid differentiation protein 2 (MD2) and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. |
| PC-26584 |
TLR4-IN-C34
TLR4 inhibitor
|
TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| PC-26537 |
TH1027
TLR8 inhibitor
|
TH1027 is a highly potent and specific inhibitor of TLR8, dose-dependently inhibited R848-or ssRNA06-induced TLR8 activation with IC50 of 30 nM. |
