TLR9 inhibitor 18 |CAS:1351978-48-7 Probechem Biochemicals

Chemical Structure : TLR9 inhibitor 18

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TLR9 inhibitor 18

货号: PC-61096Not For Human Use, Lab Use Only.

TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM).
TLR9 inhibitor 18 inhibits CpG-induced IL-6 production in mouse spleen and human PBMCs with IC50 of 74 and 244 nM, respectively.
TLR9 inhibitor 18 inhibits CpG-induced IL-6 production with ED50 of 0.8 mg/kg in mice, has great potential in the treatment of TLR9-mediated systemic uncontrollable inflammatory response like sepsis.

物理化学性质&存储条件

分子量	452.603
分子式	C25H36N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-(7-(3-morpholinopropyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl)phenyl)piperazin-1-yl)ethan-1-ol

参考文献

1. Watanabe M, et al. ACS Med Chem Lett. 2014 Oct 2;5(11):1235-9.