Telratolimod |CAS:1359993-59-1 Probechem Biochemicals

Chemical Structure : Telratolimod

CAS No.: 1359993-59-1

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Telratolimod (MEDI 9197;3M 052)

货号: PC-61400Not For Human Use, Lab Use Only.

Telratolimod (MEDI 9197, 3M 052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release.

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生物&药学活性

Telratolimod (MEDI 9197, 3M 052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release.
Telratolimod (MEDI 9197, 3M 052) induces local innate immune activation as well as systemic, antigen-specific CD8+ T cell responses which suppressed distant, uninjected tumors; is currently under clinical development for use in vaccines and cancer therapy.

物理化学性质&存储条件

分子量	593.901
分子式	C36H59N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{4-[(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)oxy]butyl}octadecanamide

参考文献

1. Singh M, et al. J Immunol. 2014 Nov 1;193(9):4722-31.

2. Van Hoeven N, et al. Sci Rep. 2017 Apr 21;7:46426.

Telratolimod (MEDI 9197;3M 052)

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物理化学性质&存储条件

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Telratolimod (MEDI 9197;3M 052)

生物&药学活性

物理化学性质&存储条件

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