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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-AT791
AT791

Chemical Structure : AT791

CAS No.: 1219962-49-8

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AT791 (AT-791)

货号: PC-62231Not For Human Use, Lab Use Only.

AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro.

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5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro.
AT791  shows weak activity against TLR4 (IC50>10 uM).
AT791  potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo.

物理化学性质&存储条件

分子量 397.519
分子式 C23H31N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[4-(6-(3-(dimethylamino)propoxy)benzo[d]oxazol-2-yl)phenoxy]-N,N-dimethylpropan-1-amine

参考文献

1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40.

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