1Z105 |CAS:1438280-73-9 Probechem Biochemicals

Chemical Structure : 1Z105

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1Z105 (1Z 105)

货号: PC-70318Not For Human Use, Lab Use Only.

1Z105 is a novel synthetic, orally bioavailable TLR4/MD2 ligand, significantly reduces the IL-6 secretion by subsequent challenge with LPS at 0.63 uM.

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生物&药学活性

1Z105 is a novel synthetic, orally bioavailable TLR4/MD2 ligand, significantly reduces the IL-6 secretion by subsequent challenge with LPS at 0.63 uM.
1Z105 desensitizes cells to subsequent TLR activation.
1Z105 prevents lethal liver damage in LPS treated galatosamine-conditioned mice, also prevents arthritis in an autoantibody-driven murine model.

物理化学性质&存储条件

分子量	446.569
分子式	C25H26N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclohexyl-2-((5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide

参考文献

1. Hayashi T, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):330-40.

2. Rajaiah R, et al. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6.

3. Goff PH, et al. J Virol. 2015 Mar;89(6):3221-35.

1Z105 (1Z 105)

生物&药学活性

物理化学性质&存储条件

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1Z105 (1Z 105)

生物&药学活性

物理化学性质&存储条件

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