TL2-C29 (TLR2 inhibitor C29) | TLR2 inhibitor | Probechem Biochemicals

Chemical Structure : TL2-C29

CAS No.: 363600-92-4

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TL2-C29 (TLR2 inhibitor C29, TLR2-IN-C29)

货号: PC-42165Not For Human Use, Lab Use Only.

TL2-C29 (TLR2 inhibitor C29) is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells.

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5 mg	￥1480	In stock
10 mg	￥2380	In stock
25 mg	￥3880	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

TL2-C29 (TLR2 inhibitor C29) is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells.
TLR2 inhibitor C29 targets the BB loop pocket of TLR2 TIR domain.
TLR2 inhibitor C29 inhibits TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages, does not inhibit signaling induced by other TLR agonists and TNF-α.
TLR2 inhibitor C29 blocks robust MAPK activation, reduces NF-κB activation, and prevents P3C-induced degradation of IκBα.

物理化学性质&存储条件

分子量	285.2946
分子式	C16H15NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-

参考文献

1. Mistry P, et al. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60.

TL2-C29 (TLR2 inhibitor C29, TLR2-IN-C29)

生物&药学活性

物理化学性质&存储条件

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TL2-C29 (TLR2 inhibitor C29, TLR2-IN-C29)

生物&药学活性

物理化学性质&存储条件

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