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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-Motolimod
Motolimod

Chemical Structure : Motolimod

CAS No.: 926927-61-9

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Motolimod (VTX-2337, VTX2337 )

货号: PC-20227Not For Human Use, Lab Use Only.

Motolimod (VTX-2337) is a potent, selective small-molecule TLR8 agonist, stimulates PBMCs to produce TNFα and IL-12 with EC50 of 140 and 120 nM, respectively.

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50 mg ￥5480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Motolimod (VTX-2337) is a potent, selective small-molecule TLR8 agonist, stimulates PBMCs to produce TNFα and IL-12 with EC50 of 140 and 120 nM, respectively.
VTX-2337 selectively activated TLR8, but not HEK293 cells transfected other TLRs (TLR2, 3, 4, 5, and 9), 30-fold over TLR7.
VTX-2337 drives mDCs and monocytes to produce IL-12 and TNFα via NF-κB activation, but not pDCs.
VTX-2337 stimulates the production of other immune mediators including IFNγ, activates NK cells to produce IFNγ.
VTX-2337 augments the lytic function of NK cells and enhances ADCC, enhances ADCC in donors with different SNP on FcγR3A.
VTX-2337 enhances rituximab-mediated ADCC, including individuals with FcγR3A genotypes associated with a reduced affinity for therapeutic monoclonal antibodies.

物理化学性质&存储条件

分子量 458.61
分子式 C28H34N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

参考文献

1. Dietsch GN, et al. Clin Cancer Res. 2015 Dec 15;21(24):5445-52.

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