DSR-6434 | TLR7 agonist | Probechem Biochemicals

Chemical Structure : DSR-6434

CAS No.: 1059070-10-8

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DSR-6434 (DSR6434)

货号: PC-20226Not For Human Use, Lab Use Only.

DSR-6434 (DSR6434) is a highly potent, specific TLR7 agonist with EC50 of 7.2 nM (hTLR7) and 4.6 nM (mTLR7) for stimulating reporter gene activity in HEK293 cells expressing TLR7.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

DSR-6434 (DSR6434) is a highly potent, specific TLR7 agonist with EC50 of 7.2 nM (hTLR7) and 4.6 nM (mTLR7) for stimulating reporter gene activity in HEK293 cells expressing TLR7.
DSR-6434 shows no acitvity in HEK293 cells expressing the structurally similar hTLR8 or hTLR9.
DSR-6434 induces type 1 interferon and activation of T and B lymphocytes, NK and NKT cells.
DSR-6434 intravenous administration enhances the efficacy of ionizing radiation (IR) and leads to improved survival in mice bearing either CT26 or KHT tumors.
DSR-6434 in combination with IR primes an antitumor CD8+ T-cell response leading to improved survival in syngeneic models of colorectal carcinoma and fibrosarcoma.

物理化学性质&存储条件

分子量	400.49
分子式	C19H28N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one

参考文献

1. Nakamura T, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):669-72.

2. Adlard AL, et al. Int J Cancer. 2014 Aug 15;135(4):820-9.

DSR-6434 (DSR6434)

生物&药学活性

物理化学性质&存储条件

参考文献

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DSR-6434 (DSR6434)

生物&药学活性

物理化学性质&存储条件

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