CU-CPT17e

Chemical Structure : CU-CPT17e

CAS No.: 2109805-75-4

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货号: PC-20231Not For Human Use, Lab Use Only.

CU-CPT17e is a multi-TLR agonist withEC50 of 4.8 μM, 13.4 μM and 5.7 μM for strong NF-κB activation on hTLR 3, 8 and 9 respectively.

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5 mg	￥3980	In stock
10 mg	￥5880	In stock
25 mg	￥8980	In stock
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生物&药学活性

CU-CPT17e is a multi-TLR agonist withEC50 of 4.8 μM, 13.4 μM and 5.7 μM for strong NF-κB activation on hTLR 3, 8 and 9 respectively.
CU-CPT17e shows negligible or no NF-κB activation via hTLR 2, 4, 5 and 7.
CU-CPT17e also exhibits significant cytotoxic activity, inhibiting the growth of cervical HeLa cancer cells (IC50 = 2.7 μM) by inducing apoptosis.

物理化学性质&存储条件

分子量	504.50
分子式	C27H24N2O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-bis((4-nitrobenzyl)oxy)-2',3',5',6'-tetrahydrospiro[chromene-2,4'-pyran]

参考文献

1. Zhang L, et al. J Med Chem. 2017;60:5029–5044.

2. Anindya Sarkar, et al. Med Chem Res. 2021 Jul;30(7):1377-1385.

CU-CPT17e

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