NSF-951 | TLR4 agonist | Probechem Biochemicals

Chemical Structure : NSF-951

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NSF-951 (NSF951, ZINC67299692)

货号: PC-25826Not For Human Use, Lab Use Only.

NSF-951 is a small molecule TLR4 agonist with binding KD of 16.01 uM, induces the pro-inflammatory cytokines via MyD88/TRIF signalling.

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生物&药学活性

NSF-951 is a small molecule TLR4 agonist with binding KD of 16.01 uM, induces the pro-inflammatory cytokines via MyD88/TRIF signalling.
NSF-951 induces the pro-inflammatory cytokines via MyD88/TRIF signalling through p38 and JNK-dependent MAPK pathway.
NSF-951 significantly upregulates the expression of these cytokines suggesting some TRIF-TRAM pathway involvement.
NSF-951 is a potent adjuvant capable of enhancing antigen-specific immune responses both alone and in combination with Alum.

物理化学性质&存储条件

分子量	436.53
分子式	C23H24N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-ethylbenzyl)-2-((3-(furan-2-ylmethyl)-6-methyl-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)thio)acetamide

参考文献

1. Kadivella M, et al. Commun Biol. 2025 Sep 29;8(1):1382.

NSF-951 (NSF951, ZINC67299692)

生物&药学活性

物理化学性质&存储条件

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NSF-951 (NSF951, ZINC67299692)

生物&药学活性

物理化学性质&存储条件

参考文献

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