L48H37

Chemical Structure : L48H37

CAS No.: 343307-76-6

加入收藏

货号: PC-26660Not For Human Use, Lab Use Only.

L48H37 is a curcumin analog that specifically targets myeloid differentiation protein 2 (MD2) and inhibits the interaction and signaling transduction of LPS-TLR4/MD2.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

L48H37 is a curcumin analog that specifically targets myeloid differentiation protein 2 (MD2) and inhibits the interaction and signaling transduction of LPS-TLR4/MD2.
L48H37 suppress LPS-induced mitogen-activated protein kinase phosphorylation and nuclear factor κB activation in macrophages.
L48H37 also dose dependently inhibits the cytokine expression in macrophages and human peripheral blood mononuclear cells stimulated by LPS.
L48H37 significantly improved survival and protected lung injury in LPS-induced septic mice.
L48H37 inhibited the proliferation and induced apoptosis in SW1990 and ASPC-1 cells in a dose- and time-dependent manner.
L48H37 exerts a potent anti-cancer effect in PDAC, which is augmented by KMT2D deficiency.

物理化学性质&存储条件

分子量	483.56
分子式	C27H33NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one

参考文献

1. Wang Y, et al. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50.

2. Feng C, et al. Mol Carcinog. 2017 Jul;56(7):1765-1777.

3. Li SS, et al. World J Gastrointest Oncol. 2019 Aug 15;11(8):599-621.

L48H37

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

L48H37

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.