BXY-14 | TLR2 agonist | Probechem Biochemicals

Chemical Structure : BXY-14

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BXY-14 (BXY14)

货号: PC-26302Not For Human Use, Lab Use Only.

BXY-14 is a highly potent TLR2 agonist, stimulates TNF-α release with EC50 of 2.2 nM and 1.8 nM in human THP-1 cells and mBMDCs respectively.

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生物&药学活性

BXY-14 is a highly potent TLR2 agonist, stimulates TNF-α release with EC50 of 2.2 nM and 1.8 nM in human THP-1 cells and mBMDCs respectively.
BXY-14 exhibited slightly stronger TLR2-activating activity than Diprovocim in hPBMCs, with EC50 values of 0.58 nM.
BXY-14 at 10 mg/kg induced stronger total IgG, IgG1, and IgG2c responses compared to Diprovocim in C57BL/6J mice.
At 10 mg/kg, BXY-14 in combination with the anti-PD-L1 antibody atezolizumab exhibited stronger tumor growth inhibition than Diprovocim.
BXY-14 monotherapy (20 mg/kg) potently suppressed tumor growth and prolonged survival, mechanistically linked to its downregulation of PD-L1 in tumors.

物理化学性质&存储条件

分子量	646.90
分子式	C35H66O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(((2R,3R,4R,5S)-3,4-Dihydroxy-5-((R)-1-hydroxy-2-(tridecanoyloxy)ethyl)tetrahydrofuran-2-yl)oxy)-2-hydroxypropyl Tridecanoate

参考文献

1. Hongbin Jia, et al. J Med Chem. 2026 Mar 1. doi: 10.1021/acs.jmedchem.5c03709.

BXY-14 (BXY14)

生物&药学活性

物理化学性质&存储条件

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BXY-14 (BXY14)

生物&药学活性

物理化学性质&存储条件

参考文献

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