SMU-C409

Chemical Structure : SMU-C409

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货号: PC-28204Not For Human Use, Lab Use Only.

SMU-C409 is a potent, specific small molecule TLR1/2 agonist with EC50 of 65 nM, activates TLR1/2, recruits MyD88, induces NF-κB phosphorylation, and stimulates TNF-α/IL-1β secretion, induces robust immune cell activation and antitumor immunomodulation.

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生物&药学活性

SMU-C409 is a potent, specific small molecule TLR1/2 agonist with EC50 of 65 nM, activates TLR1/2, recruits MyD88, induces NF-κB phosphorylation, and stimulates TNF-α/IL-1β secretion, induces robust immune cell activation and antitumor immunomodulation.

物理化学性质&存储条件

分子量	395.54
分子式	C21H21N3OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Thiourea, N-[5,6-dihydro-3-(2-methyl-1-oxopropyl)-4H-cyclopenta[b]thien-2-yl]-N′-5-quinolinyl-

参考文献

1. Qiuyue Fu, et al. J Med Chem. 2025 Dec 25;68(24):26030-26048.

SMU-C409

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物理化学性质&存储条件

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SMU-C409

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物理化学性质&存储条件

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