SMU-H1

Chemical Structure : SMU-H1

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货号: PC-28572Not For Human Use, Lab Use Only.

SMU-H1 is a potent, selective TLR2 agonist with EC50 of 5.14 nM, binds TLR2 to recruit MyD88, activates the MAPK/NF-κB pathways, and induces proinflammatory cytokines.

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生物&药学活性

SMU-H1 is a potent, selective TLR2 agonist with EC50 of 5.14 nM, binds TLR2 to recruit MyD88, activates the MAPK/NF-κB pathways, and induces proinflammatory cytokines.
SMU-H1 shows negligible effect using HEK-Blue TLR reporter cell lines expressing hTLR3, hTLR4, hTLR7, or hTLR8.
SMU-H1 drives M1 macrophage polarization and dendritic cell activation via TLR2.
SMU-H1 enhanced immune cell activation and improved antitumor efficacy when combined with conventional anticancer drugs in vivo.

物理化学性质&存储条件

分子量	411.40
分子式	C18H16F3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-(2-(Methylamino)-5-(methylsulfonyl)phenyl)-1H-imidazole-4-yl)-5-(trifluoromethyl)phenol

参考文献

1. Yue Pan, et al. J Med Chem. 2026 Sep 24;69(18):21483-21504.

SMU-H1

生物&药学活性

物理化学性质&存储条件

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SMU-H1

生物&药学活性

物理化学性质&存储条件

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