| Cat. No. |
Product Name |
Information |
| PC-70311 |
RU-TRAAK-1
|
RU-TRAAK-1 is a poorly reversible TRAAK inhibitor, shows no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2). |
| PC-70310 |
RU-GIRK-1
GIRK2 inhibitor
|
RU-GIRK-1 is a potent GIRK2 inhibitor that inhibits GIRK2-mediated flux with an IC50 of 0.35 uM. |
| PC-60984 |
ASP2905
KCNH3 inhibitor
|
ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM. |
| PC-60945 |
TKN2
TREK channel inhibitor
|
TKN2 is a small molecule allosteric inhibitor of TREK channels with IC50 of 3.8, 1.7 and 10.3 uM for TREK-1, TREK-2 and TRAAK, respectively. |
| PC-60944 |
TKN1
TREK channel inhibitor
|
TKN1 is a small molecule allosteric inhibitor of TREK channels with IC50 of 6.5, 4.4 and 15.7 uM for TREK-1, TREK-2 and TRAAK, respectively. |
| PC-60943 |
28NH
TREK channel inhibitor
|
28NH is a small molecule allosteric inhibitor of TREK channels with IC50 of 5.0, 5.0 and 11.8 uM for TREK-1, TREK-2 and TRAAK, respectively. |
| PC-60942 |
TKDC
TREK channel inhibitor
|
TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively. |
| PC-60843 |
SB335573
hERG agonist
|
SB335573 is a potent, selective hERG potassium channel (Kv11.1) activator. |
| PC-60842 |
LUF7244
hERG inhibitor
|
LUF7244 is a negative allosteric modulator of dofetilide binding to the Kv11.1 (hERG) channel with the strongest effect at 10 uM (IC50=3.9 uM). |
| PC-60841 |
VU0405601
hERG activator
|
VU0405601 is a potent Kv11.1 (hERG) channel allosteric modulator that protects cardiac tissue from hERG-related drug-induced arrhythmias. |
| PC-60840 |
PD-118057
hERG activator
|
PD-118057 is a potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells. |
| PC-60839 |
RPR260243
hERG activator
|
RPR260243 is a potent, selective hERG potassium channel (Kv11.1) activator that dramatically slows current deactivation at 1-30 uM. |
