| Cat. No. |
Product Name |
Information |
| PC-22741 |
CAT335
TREK-1 activator
|
CAT335 is a small molecule covalent K2P2.1 (TREK-1) channel activator, selectively and irreversibly activates K2P2.1(TREK-1) S131C variant (TREK-1CG∗), but not wild-type K2P2.1(TREK-1) |
| PC-22728 |
Nigericin
Potassium ionophore, NLRP3 agonist
|
Nigericin (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes. |
| PC-22574 |
ASP0819
KCa3.1 opener
|
ASP0819 is a potent, selective and orally active intermediate conductance channel KCa3.1 (IK1) opener with EC50 and Emax values of 102.4 nM and 99.0%, and 392.9 nM and 102.4% in human and rat KCa3.1-expressing cells, respectively. |
| PC-22563 |
VU0948578
KNa1.1 (Slack) inhibitor
|
VU0948578 is a potent, selective inhibitor of WT, A934T, and G288S SLACK channel (KCNT1, KNa1.1) with IC50 of 0.70, 0.59, 0.71 µM respectively. |
| PC-22457 |
BMS-986308
ROMK inhibitor
|
BMS-986308 is a potent, selective inhibitor of renal outer medullary potassium (ROMK, Kir1.1, KCNJ1) channel with IC50 of 24 nM. |
| PC-22388 |
CPK20
KNa1.1 (Slack) inhibitor
|
CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR. |
| PC-22096 |
BMS191095
KATP opener
|
BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM. |
| PC-21845 |
Tamapin TFA
SK2 channel inhibitor
|
Tamapin TFA salt is a venom peptide from the Indian red scorpion (Mesobuthus tamulus), potent and selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2, KCNN2) with IC50 of 24 pM. |
| PC-21738 |
PNU37883A
Kir6 inhibitor
|
PNU37883A (PNU37883 hydrochloride) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker with IC50 of 6 uM and 15 uM for Kir6.1/SUR2B and Kir6.2/SUR2B, respectively. |
| PC-21737 |
Pinacidil
Potassium channel activator
|
Pinacidil (P-1134) is a potent activator of potassium channel, hyperpolarises vascular smooth muscle by opening K+-channels, significantly improves the reperfusion function and cardiac compliance and has direct cardioprotective efficacy. |
| PC-21736 |
Glibenclamide
SUR1 inhibitor
|
Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor, directly binds and blocks the SUR1 subunits of KATP. |
| PC-21735 |
VU0071063
Kir6.2/SUR1 activator
|
VU0071063 is a potent and specific Kir6.2/SUR1 opener with EC50 of 7.44 uM, inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. |
