| Cat. No. |
Product Name |
Information |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-27285 |
Tenidap
Kir2.3 agonist, 5-LOX/COX inhibitor
|
Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and cyclooxygenase (COX) with anti-inflammatory and immunomodulatory properties.
Tenidap (CP-66248) reduces A 23187-stimulated LTB4 (IC50=18 uM) and PGE2 (IC50=32 nM) synthesis. |
| PC-26570 |
CHET3
TASK-3 agonist
|
CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels, including TASK-3 homomers and TASK-3/TASK-1 heteromers, displayspotent analgesic effects. |
| PC-26491 |
KCa3.1-IN-1
KCa3.1 inhibitor
|
KCa3.1-IN-1 is a selective small-molecule extracellular inhibitor of KCa3.1 channel (KCNN4) with IC50 of 43.1 uM in duplicate whole-cell patch clamp recordings. |
| PC-26490 |
GLA-1-1
BK channel agonist
|
GLA-1-1 is a small-molecule agonist of large-conductance Ca²⁺-activated K⁺ (BK) channels with EC50 of 3.4 uM, induces autophagy flux by promoting autophagosome-lysosome fusion. |
| PC-26438 |
IQM-22110
KV4.3/KChIP modulator
|
IQM-22110 is a selective small molecule modulator of KV4.3/KChIP channels with IC50 of 28 nM and binding affinity (Kd) of 230 nM to KChIP3, selective for KV4.3/KChIP3 over KV4.3/KChIP2 and KV4.3 channels. |
| PC-26200 |
JX3212
Kir4.1 Inhibitor
|
JX3212 is a potent, specific and brain penetrant inhibitor of inwardly rectifying potassium channel 4.1 (Kir4.1, KCNJ10) with IC50 of 0.28 uM (−120 mV) and 0.19 uM (+50 mV). |
| PC-26171 |
Apamin TFA
SK channel inhibitor
|
Apamin (Apamine) TFA is a peptide neurotoxin found in apitoxin and selective small conductance Ca(2+)-activated K(+) (SK(Ca)) channel blocker, exhibits anti-inflammatory and anti-fibrotic activity. |
| PC-26170 |
Apamin
SK channel inhibitor
|
Apamin (Apamine) is a peptide neurotoxin found in apitoxin and selective small conductance Ca(2+)-activated K(+) (SK(Ca)) channel blocker, exhibits anti-inflammatory and anti-fibrotic activity. |
| PC-26105 |
ICA73
KCNQ2 activator
|
ICA‐069673 (ICA73) is a selective activator of KCNQ2 potassium channel (Kv7.2), acts within the voltage-sensor domain (VSD), shows selective effects on KCNQ2 over KCNQ3. |
| PC-26104 |
ztz240
KCNQ2 activator
|
ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels. |
| PC-26103 |
E0714
Kv7.2 agonist
|
E0714 (E-0714) is a potent, specific agonist of Kv7.2 potassium channel (KCNQ2) with EC50 of 1.9 uM and 0.021 uM for Kv7.2 and Kv7.2/7.3 currents, with no significant activation of Kv7.1/7.3/7.4/7.5. |
