ztz240 | KCNQ2 activator | Probechem Biochemicals

Chemical Structure : ztz240

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ztz240 (ztz-240)

货号: PC-26104Not For Human Use, Lab Use Only.

ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels.

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生物&药学活性

ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels.
ztz240 binds to the open-state voltage-sensor domain (VSD).
ztz240 exhibits significant anti-epilepsy activity on mouse PTZ-induced seizure model.

物理化学性质&存储条件

分子量	250.66
分子式	C12H8ClFN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-chloro-pyridin-3-yl)-4-fluorobenzamide

参考文献

1. Li P, et al. Cell Res. 2013 Sep;23(9):1106-18.

2. Li X, et al. Cell Res. 2021 Jan;31(1):52-61.

3. Zhaobing Gao, et al. J Biol Chem. 2010 Sep 3;285(36):28322-32.

ztz240 (ztz-240)

生物&药学活性

物理化学性质&存储条件

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ztz240 (ztz-240)

生物&药学活性

物理化学性质&存储条件

参考文献

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