E0714 | Kv7.2 agonist | Probechem Biochemicals

Chemical Structure : E0714

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E0714 (E-0714)

货号: PC-26103Not For Human Use, Lab Use Only.

E0714 (E-0714) is a potent, specific agonist of Kv7.2 potassium channel (KCNQ2) with EC50 of 1.9 uM and 0.021 uM for Kv7.2 and Kv7.2/7.3 currents, with no significant activation of Kv7.1/7.3/7.4/7.5.

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生物&药学活性

E0714 (E-0714) is a potent, specific agonist of Kv7.2 potassium channel (KCNQ2) with EC50 of 1.9 uM and 0.021 uM for Kv7.2 and Kv7.2/7.3 currents, with no significant activation of Kv7.1/7.3/7.4/7.5.
E0714 targets the Kv7.2-specific residues F112, Y118, and N289, which are responsible for the compound's subtype-selective activation.
E0714 demonstrated potent antiepileptic activity in classic seizure models, including pentylenetetrazol (PTZ)-induced seizure model, maximal electroshock (MES) model and 6 Hz electrical stimulation model.
E0714 did not impair motor coordination in mice in the rotarod test.

物理化学性质&存储条件

分子量	347.37
分子式	C20H17N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-Benzamidophenyl)-N-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

参考文献

1. Qiao K, et al. J Med Chem. 2026 Feb 19. doi: 10.1021/acs.jmedchem.5c03052.

E0714 (E-0714)

生物&药学活性

物理化学性质&存储条件

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E0714 (E-0714)

生物&药学活性

物理化学性质&存储条件

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