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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-Tenidap
Tenidap

Chemical Structure : Tenidap

CAS No.: 120210-48-2

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Tenidap (CP-66248, CP66248)

货号: PC-27285Not For Human Use, Lab Use Only.

Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and cyclooxygenase (COX) with anti-inflammatory and immunomodulatory properties.
Tenidap (CP-66248) reduces A 23187-stimulated LTB4 (IC50=18 uM) and PGE2 (IC50=32 nM) synthesis.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and cyclooxygenase (COX) with anti-inflammatory and immunomodulatory properties.
Tenidap (CP-66248) reduces A 23187-stimulated LTB4 (IC50=18 uM) and PGE2 (IC50=32 nM) synthesis.
Tenidap (CP-66248) Inhibits arachidonic acid-induced LTB4 and PGE2 production with IC50 of 13 uM and 65 nM, respectively.
Tenidap (CP-66248) significantly inhibits the production of the pro-inflammatory cytokines, interleukin-1, interleukin-6 and tumour necrosis factor in human cell lines, and inhibits cytokine-mediated processes such as cartilage degradation, bone resorption, metalloprotease synthesis, endothelial cell adhesion and monocyte differentiation.

物理化学性质&存储条件

分子量 320.75
分子式 C14H9ClN2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-5-Chloro-3-(hydroxy(thiophen-2-yl)methylene)-2-oxoindoline-1-carboxamide

参考文献

1. Moilanen E, et al. Eicosanoids. 1988;1(1):35-9.

2. Beales PE, et al. Diabete Metab. 1992 Jan-Feb;18(1):48-53.

3. Otterness IG, et al. Cytokine. 1991 Jul;3(4):277-83.

4. Cleveland PL, et al. Cell Calcium. 1993 Jan;14(1):1-16.

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